Focal adhesions come unstuck
نویسندگان
چکیده
منابع مشابه
Focal adhesions come unstuck
Focal adhesions come unstuck C rawling cells pick up after themselves before moving on. Ezratty et al. (1) show that cells use the endocytic protein clathrin to reabsorb the integrin receptors that attach them to surfaces, instead of simply leaving the molecules behind. Cells on the go gain traction by forming focal adhesions (FAs), temporary attachments to the surface. But if they can't break ...
متن کاملParietal Cortex Signals Come Unstuck in Time
Humans and other animals are surprisingly adept at estimating the duration of temporal intervals, even without the use of watches and clocks. This ability is typically studied in the lab by asking observers to indicate their estimate of the time between two external sensory events. The results of such studies confirm that humans can accurately estimate durations on a variety of time scales. Alt...
متن کاملFocal adhesions
What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
متن کاملLate endosomes uproot focal adhesions
Keeping DNA replication below PAR T he polarity proteins PAR-4 and PAR-1 delay cell division in early C. elegans embryos by inhibiting DNA repli-cation, Benkemoun et al. reveal. Cells must divide at the right time during development. This is true from the get-go in C. elegans embryos where, at the two-cell stage, the anterior blastomere divides while its smaller, posterior sister is still in S ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2009
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb.1875if